Sub-minimum inhibitory concentrations of colistin and polymyxin B promote Acinetobacter baumannii biofilm formation
نویسندگان
چکیده
منابع مشابه
Sub-minimum inhibitory concentrations of colistin and polymyxin B promote Acinetobacter baumannii biofilm formation
We investigated the numbers of planktonic and biofilm cells and the expression levels of genes encoding efflux pumps and biofilm-related proteins in 10 clinical isolates of multi-drug resistant Acinetobacter baumannii (MDRA) as well as in its standard strain ATCC 19606 in the presence of colistin (CST), polymyxin B (PMB), minomycin (MIN), and tigecycline (TGC) at their respective sub-MICs. The ...
متن کاملThe association of biofilm formation and sub-minimal inhibitory concentrations of antimicrobial agents
Introduction: Although bacteria producing biofilm are more resistance to antimicrobial agents, biofilm formation can stimulated by sub-minimal inhibitory concentrations (sub-MICs) of some antimicrobial agents. Therefore, we designed present study to investigate the in vitro efficacy of several antibiotics (including ceftazidime, piperacillin, ticarcillin, carbenicillin, aztreonam, merop...
متن کاملBiofilm formation in Acinetobacter baumannii.
Acinetobacter baumannii has received much attention in recent years because of its increasing involvement in a number of severe infections and outbreaks occurring in clinical settings, and presumably related to its ability to survive and persist in hospital environments. The treatment of infections caused by A. baumannii nosocomial strains has become increasingly problematic, due to their intri...
متن کاملIron and Acinetobacter baumannii Biofilm Formation
Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of this bacterium is mainly due to its multidrug-resistance and ability to form biofilm on abiotic surfaces, which facilitate long-term persistence in the hospital setting. Given the crucial role of iron in A. baumannii nutrition and pathogenicity, iron metabolism has bee...
متن کاملColistin-resistant Acinetobacter baumannii clinical strains deficient in biofilm
32 In two pairs of clinical colistin-susceptible/colistin-resistant (ColS/ColR) Acinetobacter 33 baumannii, ColR strains showed significantly decreased biofilm formation in static and dynamic 34 assays (P<0.001) and lower relative fitness (P<0.05) compared with ColS. Whole genome 35 sequencing comparison of strain pairs identified in one ColR strain a *241K change in LpsB 36 (involved in LPS sy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0194556